PD 90780

• Description:

  PD 90780 is a non peptide antagonist of nerve growth factor (NGF) . PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively[1] .

• UNSPSC:

  12352005

• Target:

  Trk Receptor

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling; Protein Tyrosine Kinase/RTK

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/pd-90780.html

• Purity:

  99.0

• Solubility:

  DMSO : 31.25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  CN1C2=CC(C(O)=O)=NN2C(C3=CC(NC(C4=CC=CC=C4)=O)=CC=C13)=O

• Molecular Formula:

  C19H14N4O4

• Molecular Weight:

  362.34

• References & Citations:

  [1]Colquhoun A , et al. Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7- (benzolylamino) -4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J Pharmacol Exp Ther. 2004 Aug;310 (2) :505-11.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [77422-99-2]