7-Nitroindole

• Description:

  7-Nitroindole is a cleavable base analog. 7-nitroindole nucleoside is a photochemical precursor, which is used to specifically generate 2'-deoxyribonolactone oxidative damage sites in DNA strands. 7-Nitroindole can be used for the study of photo-controlled DNA breakage tools[1][2].

• UNSPSC:

  12352200

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  DNA/RNA Synthesis

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/7-nitroindole.html

• Purity:

  99.99

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=[N+](C1=CC=CC2=C1NC=C2)[O-]

• Molecular Formula:

  C8H6N2O2

• Molecular Weight:

  162.15

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Kotera M, et al. The 7-nitroindole nucleoside as a photochemical precursor of 2'-deoxyribonolactone: access to DNA fragments containing this oxidative abasic lesion. Chemistry. 2000 Nov 17;6 (22) :4163-9. |[2]Crey-Desbiolles C, et al. Hybridization properties and enzymatic replication of oligonucleotides containing the photocleavable 7-nitroindole base analog. Nucleic Acids Res. 2005 Mar 14;33 (5) :1532-43.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Biochemical Assay Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  [6960-42-5]