5-Nitroindole

• Description:

  5-Nitroindole is a mutagenic nitroarene and universal base analog. 5-Nitroindole significantly reduces the cellular adenylate energy charge by decreasing ATP levels and increasing AMP levels. 5-Nitroindole inhibits lipid peroxidation[1][2].

• UNSPSC:

  12352200

• Hazard Statement:

  H302, H318

• Target:

  ATP Synthase; Biochemical Assay Reagents

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Membrane Transporter/Ion Channel; Others

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/5-nitroindole.html

• Purity:

  99.30

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=[N+]([O-])C1=CC2=C(NC=C2)C=C1

• Molecular Formula:

  C8H6N2O2

• Molecular Weight:

  162.15

• Precautions:

  H302, H318

• References & Citations:

  [1]Dubin M, et al. Effect of 5-nitroindole on adenylate energy charge, oxidative phosphorylation, and lipid peroxidation in rat hepatocytes. Biochem Pharmacol. 1994 Oct 7;48 (7) :1483-92. |[2]Loakes D, et al. 5-Nitroindole as an universal base analogue. Nucleic Acids Res. 1994 Oct 11;22 (20) :4039-43.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Biochemical Assay Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  [6146-52-7]