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7-Nitroindazole

CAT: 0804-HY-69019-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-69019-01Size:500 mg
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Description
7-Nitroindazole is a selective and BBB-penetrable inhibitor of nitric oxide synthase (NOS) (IC50 = 0.47 μM in mouse cerebellum) . 7-Nitroindazole does not affect blood pressure or endothelium-dependent relaxation while inhibiting nNOS in experimental animals. 7-Nitroindazole has anti-injurious and neuroprotective properties, and can be studied in research for neurological diseases such as Parkinson’s disease[1][2][3][4].
CAS Number
2942-42-9
UNSPSC
12352005
Hazard Statement
H301, H319, H351, H360
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/7-nitroindazole.html
Purity
99.09
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=[N+](C1=CC=CC2=C1NN=C2)[O-]
Molecular Formula
C7H5N3O2
Molecular Weight
163.14
Precautions
H301, H319, H351, H360
References & Citations
[1]Moore PK, et al. 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol. 1993 Feb;108 (2) :296-7.|[2]Herrero MT, et al. 7-Nitroindazole reduces L-DOPA-induced dyskinesias in non-human Parkinsonian primate. Open Biol. 2023 May;13 (5) :220370.|[3]Memarpour S, et al. Neuronal Nitric Oxide Inhibitor 7-Nitroindazole Improved Brain-Derived Neurotrophic Factor and Attenuated Brain Tissues Oxidative Damage and Learning and Memory Impairments of Hypothyroid Juvenile Rats. Neurochem Res. 2020 Nov;45 (11) :2775-2785.|[4]ilyavskii AI, et al. 7-Nitroindazole potentiates c-fos expression induced by muscle tendon vibration in the spinal cord. Muscle Nerve. 2012 Apr;45 (4) :597-602.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NNOS

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