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CP-339818

CAT: 0804-HY-114540Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-114540Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CP-339818 is a non-peptide Kv1.3 channel (IC50 = 200 nM) and Kv1.4 channel blocker. CP 339818 inhibits HCN channel with IC50s of 18.9 μM and 43.4 μM against HCN1 and HCN4 (high Cl-) . CP-339818 has significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels. CP-339818 selectively blocked Kv1.3, thereby inhibiting the activation process of human T cells. CP-339818 can be used to study the physiological functions of HCN and Kv channels[1][2][3].
CAS Number
185855-91-8
UNSPSC
12352005
Target
HCN Channel; Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cp-339818.html
Smiles
CCCCC/N=C1C=CN(CC2=CC=CC=C2)C3=C/1C=CC=C3
Molecular Formula
C21H24N2
Molecular Weight
304.43
References & Citations
[1]Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation|[2]Jacobson DA, et al. Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses. J Physiol. 2010 Sep 15;588 (Pt 18) :3525-37. |[3]Lee YT, et al. Novel pharmacological activity of loperamide and CP-339,818 on human HCN channels characterized with an automated electrophysiology assay. Eur J Pharmacol. 2008 Feb 26;581 (1-2) :97-104.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Voltage-gated potassium channel

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