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TIMP-1

CAT: 0209-103-M277Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-103-M277Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
Synonyms
Timp1; Clgi; Timp; TIMP-1
NCBI Gene ID
21857
UniProt
P12032
Accession Number
NP_035723.2
Accession Number mRNA
NM_011593.2
Chromosomal Location
X A1.3; X 6.2 cM
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Mouse recombinant TIMP-1 protein
Clone
(#6A34)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Rat
Isotype
IgG2

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