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TIMP-4

CAT: 0209-101-M126Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M126Size:100 µg
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Description
TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
Synonyms
TIMP4
NCBI Gene ID
7079
UniProt
Q99727
Accession Number
NP_003247.1
Accession Number mRNA
NM_003256
Chromosomal Location
3p25
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human recombinant TIMP-4 protein
Clone
(#9F3)
Applications
WB, IHC (P)
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

UniProtKB · Q99727

Metalloproteinase inhibitor 4

TIMP4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q99727
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TIMP4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B2R7K6
Protein keywords

PTM

Disulfide bond

Ligand

Metal-bindingZinc

Molecular function

Metalloenzyme inhibitorMetalloprotease inhibitorProtease inhibitor

Technical term

Proteomics identificationReference proteome

Cellular component

Secreted

Domain

Signal

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C0374-01TIMP-4 Antibody
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OASB01329-100UGHuman TIMP-4 Antibody
GTR18880843-01Human TIMP-4 protein
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