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TfR EC

CAT: 0209-101-M835Size: 50 µgDry Ice: NoHazardous: No
CAT#:0209-101-M835Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The Transferrin Receptor (TfR or TfR-1, designated CD71) is a type 2 transmembrane glycoprotein expressed on erythroid progenitors, muscle cells and proliferating cells as a 188 kDa disulfide-linked homodimer of 95 kDa monomers. As the major mediator of cellular iron uptake, it binds and internalizes diferric transferrin, allowing iron release at the low pH of the endosome. The human TfR cDNA encodes 760 amino acids (aa) including a 67 aa N-terminal intracellular domain, a 21 aa transmembrane domain, and a 672 aa extracellular domain (ECD) with helical, peptidase (non-functional), and ligand binding domains, including an RGD potential integrin binding site.
Synonyms
CD71 antigen; CD71; CD71TRFR; p90; T9; TfR (Transferrin R) ; TfR (TransferrinR) ; TfR; TFR1; TFRC; TR; transferrin receptor (p90, CD71) ; transferrin receptor protein 1; TRFR
NCBI Gene ID
7037
UniProt
P02786
Accession Number
NP_003225.2
Accession Number mRNA
NM_003234.3
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human recombinant TfR EC domain
Clone
(#1X34)
Applications
FC
Purification Method
Protein G chromatography
Assay Protocol
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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