Siglec-3 EC (CD33)

CAT: 0209-101-M631Size: 50 µgDry Ice: NoHazardous: No
CAT#:0209-101-M631Size:50 µg
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Description
Siglecs are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal, Ig-like V-type domain that mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains (2 to 17), a single transmembrane region, and a cytoplasmic tail. The siglecs can be broadly classified into two subgroups: siglecs-1, -2, and -4, and a siglec-3/CD33-related subgroup (siglecs-3, and -5 through -13 in primates) defined by sequence similarity and clustered gene localization. They are widely expressed on hematopoietic cells, often in a cell-type-specific manner, and siglec-4/MAG is a myelin component in Schwann cells and oligodendrocytes. Their ligands, sialic acids, are negatively charged monosaccharides found on cell-surface glycoproteins and glycolipids. Although siglec functions continue to be defined, most have intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM), implicating them in the suppression of immunoreceptor signaling. They may also participate in cell/cell interactions or act as receptors for the entry of viral or bacterial pathogens.
Synonyms
CD33; p67; SIGLEC3; SIGLEC-3
NCBI Gene ID
945
UniProt
P20138
Accession Number
NP_001763.3
Accession Number mRNA
NM_001772.3
Chromosomal Location
19q13.3
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Ant human Siglec-2
Clone
(#5C24)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG1

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214285CD33 (p67, Siglec 3, Siglec 3)
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C00850-01Gemtuzumab (Anti-Siglec-3 / CD33)
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MBS554304-01Mouse CD33 (Siglec-3) Recombinant
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