IL-10 receptor beta

• Description:

  IL-10 mediates its biological activities via binding to a heteromeric complex of two distinct type II cytokine receptor subunits, the ligand binding subunit IL-10 R alpha (IL-10 R1) and the signal-transducing accessory subunit IL-10 R beta (IL-10 R2) . IL-10 R alpha is specific for IL-10 and expressed by most hemopoietic cells. IL-10 R beta is a widely expressed shared subunit for IL-10, IL-22, IL-26 and the IFNl proteins IL-28A, IL-28B and IL-29.

• Synonyms:

  IL10RB; CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2

• NCBI Gene ID:

  3588

• UniProt:

  Q08334

• Accession Number:

  NP_000619.3

• Accession Number mRNA:

  NM_000628.4

• Chromosomal Location:

  21q22.1-q22.2; 21q22.11

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Recombinant human IL-10 Rbeta EC domain

• Clone:

  (#8R24)

• Applications:

  WB, N

• Purification Method:

  Protein A/G chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Mouse

• Isotype:

  IgG1