FGF-21

• Description:

  FGF-21 is a secreted growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-21, in the presence of betaKlotho as a protein cofactor, signals through the FGFR 1c and 4 receptors and stimulates insulin independent glucose uptake by adipocytes. Recombinant human FGF-21 is a 19.5 kDa protein containing 182 amino acid residues.

• Synonyms:

  FGF21

• NCBI Gene ID:

  26291

• UniProt:

  Q9NSA1

• Accession Number:

  NP_061986.1

• Accession Number mRNA:

  NM_019113

• Chromosomal Location:

  19q13.1-qter

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  MHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSP ESLLQLKALK PGVIQILGVK TSRFLCQRPD GALYGSLHFD PEACSFRELL LEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPALPEP PGILAPQPPD VGSSDPLSMV GPSQGRSPSY AS

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 90% by SDS-PAGE & HPLC analyses

• Bioactivity:

  FGF-21, in the absence of betaKlotho, shows weak activity of thymidine uptake by BaF3 cells expressing FGF receptors.

• Length:

  182

• Form:

  Lyophilized

• Molecular Weight:

  19.5 kDa

• Host or Source:

  E. coli