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CEACAM-1 (dN)

CAT: 0209-102-PA102SSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-102-PA102SSize:100 µg
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Description
Carcinoembryonic antigen (CEA) -related cell adhesion molecule 1 (CEACAM1; also BGP) is a 160 kDa member of the CEACAM branch of the CEA gene family of the immunoglobulin superfamily (1-3) . It is one of seven human CEACAM subfamily genes that are essentially divided equally between type I trans-membrane proteins (CEACAM1, 3-4) and GPI-linked molecules (CEACAM5-8) . There is no CEACAM2 in human. The gene for human CEACAM1 codes for a 526 amino acid (aa) type I transmembrane protein that contains a 34 aa signal sequence, a 394 aa extracellular domain (ECD), a 24 aa transmembrane segment, and a 74aa cytoplasmic region (4, 5) . The ECD contains one N-terminal V-type followed by three C2-type Ig-like domains. It shows considerable glycosylation (1) . The cytoplasmic region shows one ITIM motif and a calmodulin binding site (1-3) . There are three soluble and seven transmembrane isoforms, with variations occurring in both the ECD and cytoplasmic region. All ten alternate splice forms contain the V-type Ig-like domain (aa’s 35-142) . The three soluble forms also contain the first two C2-type Ig like domains (aa’s 145 317), with differences coming in the third C2-type Ig- like domain (6) . The seven transmembrane isoforms are highly divergent. Full-length mouse and rat CEACAM1 are approximately 57% aa identical to human CEACAM1; in the V-type Ig-like domain, they are 58% and 56% aa identical, respectively. The full-length molecule is found on neutrophils, bile duct epithelium, activated NK cells, colonic columnar epithelium and endothelium.
Synonyms
CEACAM1; BGP; BGP1; BGPI, CD66a
NCBI Gene ID
634
UniProt
P13688
Accession Number
NP_001192273.1
Accession Number mRNA
NM_001205344
Chromosomal Location
19q13.2
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human sCEA-1 (ΔN)
Clone
Rabbit IgG
Applications
E, WB, FC
Purification Method
Protein A purified
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Bioactivity
Western Blot: Use 2-5 µg/ml
Form
Lyophilized
Buffer
PBS
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
Host or Source
Rabbit

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