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Endothelin-1/ET-1

CAT: 0209-102-PA35Size: 200 µgDry Ice: NoHazardous: No
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CAT#:0209-102-PA35Size:200 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. ET-1 acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion. A recent study has shown that ET-1 is involved in the activation of transcription factors such as NF-kappaB and expression of proinflammatory cytokines including TNF-alpha, IL-1, and IL-6. It has been also indicated that during endotoxaemia, the plasma level of ET-1 is increased in various animal species. Some authors indicate a clear correlation between endothelin plasma level and morbidity/mortality rate in septic patients. These pathological effects of ET-1 may be abrogated at least partly by endothelin receptor blockade. ET-1 receptor antagonists may be useful for prevention of various vascular diseases.
Synonyms
Preproendothelin-1, PPET-1, ET-1, EDN1
NCBI Gene ID
1906
UniProt
P05305
Accession Number
NP_001946.3
Accession Number mRNA
NM_01955.4
Reactivity
Anti-Human
Cross Reactivity
Human
Clone
Rabbit IgG
Applications
WB
Purification Method
Protein A purified
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Bioactivity
Western Blot: Use 1-5 µg/ml
Form
Lyophilized from PBS
Buffer
PBS
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
Host or Source
Rabbit

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