DN-1289

• Target :

  JNK|||DNA Alkylation

• Related Pathways :

  DNA Damage/DNA Repair|||MAPK

• Purity :

  >99.99%

• Bioactivity :

  DN-1289 is an orally available, blood-brain barrier-crossing, selective and potent inhibitor with an IC50 value of 17 nM for di-leucine zipper kinase (DLK) and 40 nM for leucine zipper-bearing kinase (LZK) .DN-1289 significantly inhibited optic nerve crush (ONC) -induced p-c-Jun in a mouse model.

• Smiles :

  NC1=C(OC(F)F)N=C(C2=NC(N3[C@@H]4CO[C@H](C3)C4)=NC(N5CC(F)(CC5)F)=C2)C=N1

• Molecular Formula :

  C18H19F4N7O2

• Molecular Weight :

  441.38

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C