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CCL-19 (MIP-3 beta)

CAT: 0209-101-M262Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-101-M262Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CCL19, also known as MIP3β and ELC (EBI1Ligand Chemokine), is a 77 amino acid (aa) β chemokine that is distantly related to other β chemokines (20-30% aa sequence identity) . The gene for MIP3β has been mapped to chromosome 9p13 rather than chromosome 17 where the genes for many human β chemokines are clustered. MIP3β is constitutively expressed in various lymphoid tissues (including thymus, lymph nodes, appendix and spleen) . The expression of MIP3β is downregulated by the antiinflammatory cytokine IL10. Recombinant MIP3β is chemotactic for cultured human lymphocytes. MIP3β is a ligand for CCR7 (previously referred to as the EpsteinBarr virus-induced gene 1 (EBI1) orphan receptor), a chemokine receptor that is expressed in various lymphoid tissues and activated B and T lymphocytes. CCR7 is strongly upregulated in B cells infected with EpsteinBarr virus and T cells infected with herpesvirus 6 or 7.
Synonyms
CCL19; ELC; CKb11; MIP3B; MIP-3b; SCYA19
NCBI Gene ID
6363
UniProt
Q99731
Accession Number
NP_006265
Accession Number mRNA
NM_006274
Chromosomal Location
9p13
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human CCL-19
Clone
(#11B4)
Applications
WB, IHC
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Host or Source
Mouse
Isotype
IgG2