Maculatin 1.1 (TFA)

• UNSPSC Description:

  Maculatin 1.1 TFA is an antimicrobial peptide with an MIC against Staphylococcus aureus of 7 μM. Maculatin 1.1 TFA can perforate the bacterial membrane of Staphylococcus aureus, causing bacterial death[1].

• Target Antigen:

  Bacterial

• Type:

  Peptides

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/maculatin-1-1-tfa.html

• Purity:

  96.93

• Solubility:

  10 mM in DMSO

• Smiles:

  NCC(N[C@@H](CC(C)C)C(N[C@@H](CC1=CC=CC=C1)C(NCC(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC2=CN=CN2)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N3[C@@H](CCC3)C(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N)=O)CC4=CC=CC=C4)=O)CC5=CN=CN5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O.[x]

• Molecular Weight:

  2145.55 (free base)

• References & Citations:

  [1]Sani MA, et al. Maculatin 1.1 disrupts Staphylococcus aureus lipid membranes via a pore mechanism. Antimicrob Agents Chemother. 2013 Aug;57(8):3593-600.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  No Development Reported