Notch 1 (TFA)

CAT: 0804-HY-P1985A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P1985A-01Size:5 mg
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Description
Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types[1].
UNSPSC
12352209
Target
Notch
Type
Peptides
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/notch-1-tfa.html
Purity
95.03
Solubility
H2O : 18.52 mg/mL (ultrasonic;adjust pH to 9 with NaOH)
Smiles
O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCC(N)=O)C(N[C@@H](CS)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CS)C(N[C@@H](CCC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CS)N.OC(C(F)(F)F)=O.[x]
Molecular Formula
C62H97N15O22S3.xC2HF3O2
Molecular Weight
1500.72 (free base)
References & Citations
[1]NOTCH1 notch receptor 1 [Homo sapiens (human) ] Gene ID: 4851, updated on 28-Oct-2019.|[2]Stoyanova T, et al. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Oct 18;113 (42) :E6457-E6466.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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