Products for Research Use Only
RegisterLogin

AG-494

CAT: 0804-HY-101042-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-101042-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 μM) . AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis[1][2][3].
CAS Number
133550-35-3
Product Name Alternative
Tyrphostin AG 494
UNSPSC
12352005
Hazard Statement
H301, H315, H319
Target
CDK; EGFR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ag-494.html
Purity
98.69
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2
Molecular Formula
C16H12N2O3
Molecular Weight
280.28
Precautions
H301, H315, H319
References & Citations
[1]Gazit A, et al. Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J Med Chem. 1991;34 (6) :1896-1907.|[2]Liu X, Qin J, et al. Cross-talk between EGF and BMP9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cells. J Cell Mol Med. 2013;17 (9) :1160-1172.|[3]Jihee Lee Kang, et al. SILICA-INDUCED NUCLEAR FACTOR- k B ACTIVATION: INVOLVEMENT OF REACTIVE OXYGEN SPECIES AND PROTEIN TYROSINE KINASE ACTIVATION. Journal of Toxicology and Environmental Health, Part A.|[4]Osherov N, et al. Tyrphostin AG 494 blocks Cdk2 activation. FEBS Lett. 1997;410 (2-3) :187-190.|[5]Osherov N, et al. Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins. J Biol Chem. 1993 May 25;268 (15) :11134-42.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1

Chemical Information

AG 494

Tyrphostin B48 is a member of the tyrphostin family of tyrosine kinase inhibitors that inhibits epidermal growth factor receptor. (NCI)

CAS Number133550-35-3
PubChem CID5328771
IUPAC Name(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-2-enamide
Molecular FormulaC16H12N2O3
Molecular Weight280.28
XLogP2.7
Topological Polar Surface Area93.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count21
Formal Charge0
Complexity446
SMILES
C1=CC=C(C=C1)NC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N
InChI
InChI=1S/C16H12N2O3/c17-10-12(8-11-6-7-14(19)15(20)9-11)16(21)18-13-4-2-1-3-5-13/h1-9,19-20H,(H,18,21)/b12-8+
InChIKey
HKHOVJYOELRGMV-XYOKQWHBSA-N
Chemical Structure
2D Structure
2D structure of AG 494
CAS: 133550-35-3
CID: 5328771
Formula: C16H12N2O3
MW: 280.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight280.28
XLogP32.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass280.08479225
Monoisotopic Mass280.08479225
Topological Polar Surface Area93.4 Ų
Heavy Atom Count21
Formal Charge0
Complexity446
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-128773MRL-494
HY-126230PAT-494
HY-171897E10i-494
HY-128773A-01MRL-494 (hydrochloride)
HY-W953518CRBN ligand-494
HY-126230A(Rac) -PAT-494
HY-116111AG 370
HY-119715-01AG-012986
HY-108931-01AG 1406
HY-15492-01AG-13958

Alternative Products

CatalogName
254558-01AG 494
BML-EI228-0010AG-494
A17142-200AG-494 200mg
A17142-100AG-494 100mg

Popular Products