AG 370

• Description :

  AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM) . AG 370 displays weak inhibition of the EGF receptor[1].

• CAS Number :

  [134036-53-6]

• UNSPSC :

  12352005

• Target :

  PDGFR

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/ag-370.html

• Purity :

  97.0

• Solubility :

  DMSO : 30 mg/mL (ultrasonic; warming)

• Smiles :

  N#C/C(C#N)=C(N)/C(C#N)=C\C1=CC=C(NC=C2)C2=C1

• Molecular Formula :

  C15H9N5

• Molecular Weight :

  259.27

• References & Citations :

  [1]M C Bryckaert, et al. Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins. Exp Cell Res. 1992 Apr;199 (2) :255-61.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PDGFR