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AG 370

CAT: 0804-HY-116111Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116111Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM) . AG 370 displays weak inhibition of the EGF receptor[1].
CAS Number
134036-53-6
UNSPSC
12352005
Target
PDGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ag-370.html
Purity
97.0
Solubility
DMSO : 30 mg/mL (ultrasonic; warming)
Smiles
N#C/C(C#N)=C(N)/C(C#N)=C\C1=CC=C(NC=C2)C2=C1
Molecular Formula
C15H9N5
Molecular Weight
259.27
References & Citations
[1]M C Bryckaert, et al. Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins. Exp Cell Res. 1992 Apr;199 (2) :255-61.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDGFR

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