AG 370

• Description:

  AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM) . AG 370 displays weak inhibition of the EGF receptor[1].

• UNSPSC:

  12352005

• Target:

  PDGFR

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/ag-370.html

• Purity:

  97.0

• Solubility:

  DMSO : 30 mg/mL (ultrasonic; warming)

• Smiles:

  N#C/C(C#N)=C(N)/C(C#N)=C\C1=CC=C(NC=C2)C2=C1

• Molecular Formula:

  C15H9N5

• Molecular Weight:

  259.27

• References & Citations:

  [1]M C Bryckaert, et al. Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins. Exp Cell Res. 1992 Apr;199 (2) :255-61.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PDGFR

• CAS Number:

  [134036-53-6]