MRL-494

CAT: 0804-HY-128773Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-128773Size:1 Each
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Description
MRL-494, an antibacterial agent, is a inhibitor of β-barrel assembly machine A (BamA) impervious to efflux and the outer membrane permeability barrier. MRL-494 can inhibits Gram-positive (MIC of 12.5 μM for Staphylococcus aureus COL) and Gram-negative (MIC of 25 μM for E. coli JCM158) bacterias[1].
CAS Number
[2434898-43-6]
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mrl-494.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(C2=NN(CC(N[C@@H]3CC[C@H](NC4=NC(NC(C5CC5)CC(NC(N)=N)=O)=NC(NC(N)=N)=N4)CC3)=O)N=N2)C=C1
Molecular Formula
C26H35FN16O2
Molecular Weight
622.66
References & Citations
[1]Hart EM, A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier. Proc Natl Acad Sci U S A. 2019 Oct 22;116 (43) :21748-21757.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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