AG 1406

• Description :

  AG 1406 (compound M19) is a HER2 inhibitor, with an IC50 of 10.57 μM for HER2 in BT474 cell and >50 μM for EGFR in EGF-3T3 cell[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H311, H331

• Target :

  EGFR

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ag-1406.html

• Purity :

  99.03

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  N#C/C(C#N)=C/C1=CC(C(C)C)=C(O)C(C(C)C)=C1

• Molecular Formula :

  C16H18N2O

• Molecular Weight :

  254.33

• Precautions :

  H301, H311, H331

• References & Citations :

  [1]Hui Chen, et al. Methods and compositions for inhibiting cell proliferative disorders. Patent, US5789427A.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [71308-34-4]