AG 1406

• UNSPSC Description:

  AG 1406 (compound M19) is a HER2 inhibitor, with an IC50 of 10.57 μM for HER2 in BT474 cell and >50 μM for EGFR in EGF-3T3 cell[1].

• Target Antigen:

  EGFR

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ag-1406.html

• Purity:

  99.03

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  N#C/C(C#N)=C/C1=CC(C(C)C)=C(O)C(C(C)C)=C1

• Molecular Weight:

  254.333

• References & Citations:

  [1]Hui Chen, et al. Methods and compositions for inhibiting cell proliferative disorders. Patent, US5789427A.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  71308-34-4