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MI-538

CAT: 0804-HY-19810-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19810-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM.
CAS Number
1857417-10-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MI-538.html
Concentration
10mM
Purity
98.23
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)(F)CC(S1)=CC2=C1N=CN=C2NC3CCN(CC4=C(O)C=C(N(CC5=CNN=C5)C(C#N)=C6)C6=C4)CC3
Molecular Formula
C27H25F3N8OS
Molecular Weight
566.60
Precautions
H302, H315, H319, H335
References & Citations
[1]Borkin D, et al. Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL) . J Med Chem. 2016 Feb 11;59 (3) :892-913.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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