AG 538

• Description:

  AG 538 is a potent, competitive inhibitor of IGF-1 receptor kinase, with an IC50 of 400 nM[1].

• UNSPSC:

  12352005

• Target:

  IGF-1R

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ag-538.html

• Purity:

  99.80

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  N#C/C(C(C1=CC=C(O)C(O)=C1)=O)=C\C2=CC=C(O)C(O)=C2

• Molecular Formula:

  C16H11NO5

• Molecular Weight:

  297.26

• References & Citations:

  [1]G Blum, et al. Substrate Competitive Inhibitors of IGF-1 Receptor Kinase. Biochemistry. 2000 Dec 26;39 (51) :15705-12.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [133550-18-2]