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PARL-IN-2

CAT: 0804-HY-169380-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-169380-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PARL-IN-2 (Compound 14) is a covalent inhibitor of the mitochondrial intramembrane protease PARL with an EC50 value of 0.16 μM. PARL-IN-2 leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-2 promotes PINK1/Parkin-dependent mitophagy[1].
UNSPSC
12352005
Target
Mitophagy; PINK1/Parkin
Type
Reference compound
Related Pathways
Autophagy; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/parl-in-2.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OCC1=CC=CC=C1)C2=CC=C(CN3C(C(CC)(CC)C3=O)=O)C=C2
Molecular Formula
C22H23NO4
Molecular Weight
365.42
References & Citations
[1]Ji S, Bach K, et al. 4-Oxo-β-lactams as Covalent Inhibitors of the Mitochondrial Intramembrane Protease PARL[J]. ACS Medicinal Chemistry Letters, 2024.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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