PARL-IN-1 (TFA)

PARL-IN-1 (TFA)

• UNSPSC Description: PARL-IN-1 TFA is a potent PARL inhibitor with an IC50 value of 28 nM. PARL-IN-1 TFA inhibits PARL and leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-1 TFA promotes PINK1/Parkin-dependent mitophagy[1].
• Target Antigen: Mitophagy; PINK1/Parkin
• Type: Reference compound
• Related Pathways: Autophagy;Neuronal Signaling
• Applications: Cancer-programmed cell death
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/parl-in-1-tfa.html
• Purity: 95.01
• Smiles: O=C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(C(NCCCCC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)C.FC(F)(C(O)=O)F
• Molecular Weight: 834.92
• References & Citations: [1]Poláchová E, et, al. Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy. J Med Chem. 2023 Jan 12;66(1):251-265.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light, stored under nitrogen)
• Clinical Information: Phase 2