PARL-IN-1 (TFA)
CAT:
804-HY-152265A
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PARL-IN-1 (TFA)
- UNSPSC Description: PARL-IN-1 TFA is a potent PARL inhibitor with an IC50 value of 28 nM. PARL-IN-1 TFA inhibits PARL and leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-1 TFA promotes PINK1/Parkin-dependent mitophagy[1].
- Target Antigen: Mitophagy; PINK1/Parkin
- Type: Reference compound
- Related Pathways: Autophagy;Neuronal Signaling
- Applications: Cancer-programmed cell death
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/parl-in-1-tfa.html
- Purity: 95.01
- Smiles: O=C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(C(NCCCCC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)C.FC(F)(C(O)=O)F
- Molecular Weight: 834.92
- References & Citations: [1]Poláchová E, et, al. Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy. J Med Chem. 2023 Jan 12;66(1):251-265.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, protect from light, stored under nitrogen)
- Clinical Information: Phase 2