Nav1.3 channel inhibitor 1

Nav1.3 channel inhibitor 1

• UNSPSC Description: Nav1.3 channel inhibitor 1 (compound 15b) is a state-dependent voltage-gated sodium channel Nav1.3 inhibitor (IC50=20 nM). Nav1.3 channel inhibitor 1 can penetrate the blood-brain barrier and can be used in the research of nervous system diseases[1].
• Target Antigen: Sodium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/nav1-3-channel-inhibitor-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1C(C2=CC=C(F)C(F)=C2)C1)NC3=CC=C(S(=O)(NC4=NC=CS4)=O)C=C3
• Molecular Weight: 435.47
• References & Citations: [1]Zidar N, et al. New aryl and acylsulfonamides as state-dependent inhibitors of Nav1.3 voltage-gated sodium channel. Eur J Med Chem. 2023 Oct 5;258:115530.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported