SA-VA

CAT: 0804-HY-155685Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-155685Size:1 Each
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Description
SA-VA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-VA is able to selectively degrade VEGFR-2 and EphB4 proteins in U87 cells. SA-VA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues. SA-VA promotes apoptosis and blocks cells in S phase[1].
UNSPSC
12352005
Target
Apoptosis; Ephrin Receptor; PROTACs; VEGFR
Type
Reference compound
Related Pathways
Apoptosis; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sa-va.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC1=CN(CCCCC(N[C@@H](C(C)(C)C)C(N2[C@H](C(NCC3=CC=C(C4=C(C)N=CS4)C=C3)=O)C[C@@H](O)C2)=O)=O)N=N1)C5=NC=CC(OC6=CC=C(NC(NC7=CC=C(Cl)C(C(F)(F)F)=C7)=O)C=C6)=C5
Molecular Formula
C50H53ClF3N11O7S
Molecular Weight
1044.54
References & Citations
[1]Ru Si, et al. Discovery of intracellular self-assembly protein degraders driven by tumor-specific activatable bioorthogonal reaction. Eur J Med Chem. 2023 Sep 5;257:115497.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1; von Hippel-Lindau (VHL)

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