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CU-CPT-8m

CAT: 0804-HY-112050-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112050-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CU-CPT-8m is a specific TLR8 antagonist, with an IC50 of 67 nM.
CAS Number
125079-83-6
Product Name Alternative
TLR8-specific antagonist
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/CU-CPT-8m.html
Purity
99.98
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C2N=CC=C(C3=CC=CC(C)=C3)N2N=C1)N
Molecular Formula
C14H12N4O
Molecular Weight
252.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang S, et al. Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat Chem Biol. 2018 Jan;14 (1) :58-64.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR8

Chemical Information

CU-CPT-8m
CAS Number125079-83-6
PubChem CID15042086
IUPAC Name7-(3-methylphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
Molecular FormulaC14H12N4O
Molecular Weight252.27
XLogP1.2
Topological Polar Surface Area73.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count19
Formal Charge0
Complexity348
SMILES
CC1=CC(=CC=C1)C2=CC=NC3=C(C=NN23)C(=O)N
InChI
InChI=1S/C14H12N4O/c1-9-3-2-4-10(7-9)12-5-6-16-14-11(13(15)19)8-17-18(12)14/h2-8H,1H3,(H2,15,19)
InChIKey
HNKGGVGQAVODNJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of CU-CPT-8m
CAS: 125079-83-6
CID: 15042086
Formula: C14H12N4O
MW: 252.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight252.27
XLogP31.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass252.10111102
Monoisotopic Mass252.10111102
Topological Polar Surface Area73.3 Ų
Heavy Atom Count19
Formal Charge0
Complexity348
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BA6305-5CU-CPT-8m
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A19309-200CU-CPT-8m 200mg
A19309-5CU-CPT-8m 5mg
A19309-50CU-CPT-8m 50mg
A19309-25CU-CPT-8m 25mg
A19309-10CU-CPT-8m 10mg
A19309-1CU-CPT-8m 1mg
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