Debio-0123

• Target:

  CDK|||Wee1

• Related Pathways:

  Cell Cycle/Checkpoint

• Purity:

  0.9993

• Bioactivity:

  Debio-0123 (WEE1-IN-5) is a potent, orally available and highly specific WEE1 inhibitor with an IC 50 in the low nanomolar range. Debio-0123 inhibits phospho-CDC2 which translated into an increase in DNA damage and premature entry into mitosis. Debio-0123 increases the antitumoral activity of Carboplatin in vivo whereas neither agent was active alone [1].

• Smiles:

  CN1CCC(CC1)c1ccc(Nc2ncc3C(=O)N(CN(C)c3n2)c2c(Cl)cccc2Cl)cc1C

• Molecular Formula:

  C26H28Cl2N6O

• Molecular Weight:

  511.45

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2243882-74-6