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Debio-0123

CAT: 0931-T9864-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T9864-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2243882-74-6
Target
CDK, Wee1
Related Pathways
Cell Cycle/Checkpoint
Purity
0.9993
Bioactivity
Debio-0123 (WEE1-IN-5) is a potent, orally available and highly specific WEE1 inhibitor with an IC 50 in the low nanomolar range. Debio-0123 inhibits phospho-CDC2 which translated into an increase in DNA damage and premature entry into mitosis. Debio-0123 increases the antitumoral activity of Carboplatin in vivo whereas neither agent was active alone [1].
Smiles
CN1CCC(CC1)c1ccc(Nc2ncc3C(=O)N(CN(C)c3n2)c2c(Cl)cccc2Cl)cc1C
Molecular Formula
C26H28Cl2N6O
Molecular Weight
511.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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