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HJC-0123

CAT: 931-T70686-01Size: 25 mgDry Ice: NoHazardous: No
25 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1430420-02-2
Target
Apoptosis|||STAT|||Others|||Interleukin|||TGF-beta/Smad
Related Pathways
JAK/STAT signaling|||Apoptosis|||Immunology/Inflammation|||Others|||Stem Cells
Bioactivity
Downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significantly suppressed estrogen receptor (ER) -negative breast cancer MDA-MB-231 xenograft tumor growth in vivo (p.o.), indicating its great potential as an efficacious and orally bioavailable drug candidate for human cancer therapy.
Smiles
C(NC=1C=C2C(=CC1)C=CS2(=O)=O)(=O)C=3C4=C(N=C(C3)C5=CC=CC=C5)C=CC=C4
Molecular Formula
C24H16N2O3S
Molecular Weight
412.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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