HJC-0123

• Target:

  Apoptosis|||STAT|||Others|||Interleukin|||TGF-beta/Smad

• Related Pathways:

  JAK/STAT signaling|||Apoptosis|||Immunology/Inflammation|||Others|||Stem Cells

• Bioactivity:

  Downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significantly suppressed estrogen receptor (ER) -negative breast cancer MDA-MB-231 xenograft tumor growth in vivo (p.o.), indicating its great potential as an efficacious and orally bioavailable drug candidate for human cancer therapy.

• Smiles:

  C(NC=1C=C2C(=CC1)C=CS2(=O)=O)(=O)C=3C4=C(N=C(C3)C5=CC=CC=C5)C=CC=C4

• Molecular Formula:

  C24H16N2O3S

• Molecular Weight:

  412.46

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1430420-02-2