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GDC-0575

CAT: 0931-T7300-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T7300-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1196541-47-5
Target
Chk
Related Pathways
Cell Cycle/Checkpoint
Purity
0.98
Bioactivity
GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor (IC50 of 1.2 nM) .
Smiles
N[C@@H]1CCCN(C1)c1c(Br)cnc2[nH]cc(NC(=O)C3CC3)c12
Molecular Formula
C16H20BrN5O
Molecular Weight
378.27
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide
CAS Number1196541-47-5
PubChem CID46917793
IUPAC NameN-[4-[(3R)-3-aminopiperidin-1-yl]-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl]cyclopropanecarboxamide
Molecular FormulaC16H20BrN5O
Molecular Weight378.27
XLogP1.4
Topological Polar Surface Area87
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count23
Formal Charge0
Complexity460
SMILES
C1C[C@H](CN(C1)C2=C3C(=CNC3=NC=C2Br)NC(=O)C4CC4)N
InChI
InChI=1S/C16H20BrN5O/c17-11-6-19-15-13(14(11)22-5-1-2-10(18)8-22)12(7-20-15)21-16(23)9-3-4-9/h6-7,9-10H,1-5,8,18H2,(H,19,20)(H,21,23)/t10-/m1/s1
InChIKey
BAZRWWGASYWYGB-SNVBAGLBSA-N
Chemical Structure
2D Structure
2D structure of (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide
CAS: 1196541-47-5
CID: 46917793
Formula: C16H20BrN5O
MW: 378.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight378.27
XLogP31.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass377.08512
Monoisotopic Mass377.08512
Topological Polar Surface Area87 Ų
Heavy Atom Count23
Formal Charge0
Complexity460
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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