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RMC-4998 formic

CAT: 0931-T206911-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206911-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
PI3K, Apoptosis, ERK, mTOR, Ras
Related Pathways
MAPK, GPCR/G Protein, Apoptosis, PI3K/Akt/mTOR signaling
Bioactivity
RMC-4998 formic is an orally active inhibitor targeting the GTP-bound state of the KRASG12C mutant. It forms a trimeric complex with intracellular CYPA and the activated KRASG12C mutant, displaying an IC50 value of 28 nM. This compound inhibits ERK signaling and induces apoptosis in KRASG12C mutant cancer cells and is utilized in tumor research.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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