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Cbl-b-IN-2

CAT: 0931-T64072-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T64072-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2503325-21-9
Target
Others, E3 Ligase Ligand-Linker Conjugate
Related Pathways
PROTAC, Others
Bioactivity
Cbl-b-IN-2 is an orally active biological compound that inhibits the E3 enzyme Casitas b lineage lymphoma proto-oncogene b (Cbl-b) in the ubiquitin proteasome pathway and can be used in the study of diseases that modulate the immune system and are susceptible to regulation by the immune system. Cbl-b-IN-2 can also be used in cancer research alone or in combination with one or more immune checkpoint inhibitors, antitumour agents and radiopharmaceuticals.
Smiles
C(C1(COC1)C2=CC(=CC=C2)N3CC=4C(C3=O)=CC(CN5C[C@@H](C)C(F)(F)CC5)=CC4C(F)(F)F)C=6N(C)C=NN6
Molecular Formula
C29H30F5N5O2
Molecular Weight
575.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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