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TRK-IN-12

CAT: 0931-T62531-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T62531-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2823342-34-1
Target
Others, Trk receptor
Related Pathways
Others, Tyrosine Kinase/Adaptors
Bioactivity
TRK-IN-12 (Compound 9e), a macrocyclic derivative, is a potent TRK inhibitor, with efficacy against TRK G595R (IC 50 = 13.1 nM) . It demonstrates significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC 50 = 0.080 μM) and exhibits superior inhibitory performance (IC 50 = 0.646 μM) compared to the control agent LOXO-101 in the Ba/F3-LMNA-NTRK1-G595R cell line [1].
Smiles
S(CCl)(=O)(=O)N1CC2=C3N(N=C2)C=CC(=N3)N(C)CC=4C(OCC1)=CC=C(F)C4
Molecular Formula
C18H19ClFN5O3S
Molecular Weight
439.89
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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