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J-1063

CAT: 0931-T62301-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T62301-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2374772-46-8
Target
Others, TGF-beta/Smad
Related Pathways
Others, Stem Cells
Bioactivity
J-1063 is a selective, orally active and potent inhibitor of ALK5 (IC50: 0.039 μM) . J-1063 inhibits inflammatory infiltration, collagen deposition, hepatocyte necrosis and exhibits anti-fibrotic effects. j-1063 has potential for liver fibrosis studies.
Smiles
C(C(NC1=CC=CC=C1)=O)N2C=C(C(=N2)C=3N=C(C)C=CC3)C4=CC=5C(S4)=CC=NC5
Molecular Formula
C24H19N5OS
Molecular Weight
425.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

2-[3-(6-methyl-2-pyridinyl)-4-thieno[3,2-c]pyridin-2-ylpyrazol-1-yl]-N-phenylacetamide
CAS Number2374772-46-8
PubChem CID155553747
IUPAC Name2-[3-(6-methyl-2-pyridinyl)-4-thieno[3,2-c]pyridin-2-ylpyrazol-1-yl]-N-phenylacetamide
Molecular FormulaC24H19N5OS
Molecular Weight425.5
XLogP3.9
Topological Polar Surface Area101
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count31
Formal Charge0
Complexity615
SMILES
CC1=NC(=CC=C1)C2=NN(C=C2C3=CC4=C(S3)C=CN=C4)CC(=O)NC5=CC=CC=C5
InChI
InChI=1S/C24H19N5OS/c1-16-6-5-9-20(26-16)24-19(22-12-17-13-25-11-10-21(17)31-22)14-29(28-24)15-23(30)27-18-7-3-2-4-8-18/h2-14H,15H2,1H3,(H,27,30)
InChIKey
YVABZJGVIULAAE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-[3-(6-methyl-2-pyridinyl)-4-thieno[3,2-c]pyridin-2-ylpyrazol-1-yl]-N-phenylacetamide
CAS: 2374772-46-8
CID: 155553747
Formula: C24H19N5OS
MW: 425.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight425.5
XLogP33.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass425.13103142
Monoisotopic Mass425.13103142
Topological Polar Surface Area101 Ų
Heavy Atom Count31
Formal Charge0
Complexity615
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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