MI-1063

• CAS Number :

  1410737-39-1

• Target :

  Ligands for Target Protein for PROTAC|||MDM-2/p53

• Related Pathways :

  PROTAC|||Apoptosis

• Bioactivity :

  MI-1063 is a DMD-2 inhibitor that prevents the MDM2-p53 interaction and activates p53's tumor-suppressing abilities. It inhibits the growth of cancer cells RS4-11 and MV4-11, with IC50 values of 179 nM and 93 nM, respectively. MI-1063 serves as a target protein ligand for the synthesis of the PROTAC degrader [MD-265].

• Smiles :

  O=C1[C@@]2(C3(N[C@@H](C(N[C@H]4CC[C@H](C(O)=O)CC4)=O)[C@@H]2C5=C(F)C(Cl)=CC=C5)CCCCC3)C=6C(N1)=CC(Cl)=CC6

• Molecular Formula :

  C30H32Cl2FN3O4

• Molecular Weight :

  588.5

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C