JMI-105

• Target:

  Parasite|||Others

• Related Pathways:

  Microbiology/Virology|||Others

• Bioactivity:

  JMI-105 has the potential as an antimalarial agent. JMI-105 is a potent inhibitor of Plasmodium falciparum falcipain-2 protease (PfFP-2) that inhibits the P. falciparum strains CQ S (3D7) and CQ R (RKL-9) growth with IC 50 values of 8.8 ?M and 14.3 ?M. In a murine model with P. berghei ANKA infection, JMI-105 significantly decreases parasitemia and prolonged host survival [1].

• Smiles:

  C (OC1=CC (C (C) C) =CC=C1C) C2=CN (N=N2) C3=CC=C (OC) C=C3

• Molecular Formula:

  C20H23N3O2

• Molecular Weight:

  337.42

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2227315-30-0