JMI-105

• Target :

  Parasite|||Others

• Related Pathways :

  Microbiology/Virology|||Others

• Bioactivity :

  JMI-105 has the potential as an antimalarial agent. JMI-105 is a potent inhibitor of Plasmodium falciparum falcipain-2 protease (PfFP-2) that inhibits the P. falciparum strains CQ S (3D7) and CQ R (RKL-9) growth with IC 50 values of 8.8 ?M and 14.3 ?M. In a murine model with P. berghei ANKA infection, JMI-105 significantly decreases parasitemia and prolonged host survival [1].

• Smiles :

  C(OC1=CC(C(C)C)=CC=C1C)C2=CN(N=N2)C3=CC=C(OC)C=C3

• Molecular Formula :

  C20H23N3O2

• Molecular Weight :

  337.42

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2227315-30-0