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JMI-105

CAT: 0931-T61058-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T61058-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2227315-30-0
Target
Parasite, Others
Related Pathways
Microbiology/Virology, Others
Bioactivity
JMI-105 has the potential as an antimalarial agent. JMI-105 is a potent inhibitor of Plasmodium falciparum falcipain-2 protease (PfFP-2) that inhibits the P. falciparum strains CQ S (3D7) and CQ R (RKL-9) growth with IC 50 values of 8.8 μM and 14.3 μM. In a murine model with P. berghei ANKA infection, JMI-105 significantly decreases parasitemia and prolonged host survival [1].
Smiles
C(OC1=CC(C(C)C)=CC=C1C)C2=CN(N=N2)C3=CC=C(OC)C=C3
Molecular Formula
C20H23N3O2
Molecular Weight
337.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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