IG-105

• Target :

  Others

• Related Pathways :

  Others

• Bioactivity :

  IG-105 is a potent microtubule inhibitor with potential anticancer activity. IG-105 inhibits microtubule assembly by binding at colchicine pocket. IG-105 shows a potent anticancer activity in vitro and in vivo and has good safety in mice. IG-105 showed a potent activity against human leukemia and solid tumors in breast, liver, prostate, lung, skin, colon, and pancreas with IC (50) values between 0.012 and 0.298 mumol/L. It was also active in drug-resistant tumor cells and not a P-glycoprotein substrate. It inhibited microtubule assembly followed by M-phase arrest, Bcl-2 inactivation, and then apoptosis through caspase pathways.

• Smiles :

  CN1C=2C(C=3C1=CC=CC3)=CC(S(NC4=C(OC)N=C(OC)C=C4)(=O)=O)=CC2

• Molecular Formula :

  C20H19N3O4S

• Molecular Weight :

  397.45

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  905978-63-4