IG-105

CAT: 0931-MF-0143268-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0143268-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
905978-63-4
Target
Others
Related Pathways
Others
Bioactivity
IG-105 is a potent microtubule inhibitor with potential anticancer activity. IG-105 inhibits microtubule assembly by binding at colchicine pocket. IG-105 shows a potent anticancer activity in vitro and in vivo and has good safety in mice. IG-105 showed a potent activity against human leukemia and solid tumors in breast, liver, prostate, lung, skin, colon, and pancreas with IC (50) values between 0.012 and 0.298 mumol/L. It was also active in drug-resistant tumor cells and not a P-glycoprotein substrate. It inhibited microtubule assembly followed by M-phase arrest, Bcl-2 inactivation, and then apoptosis through caspase pathways.
Smiles
CN1C=2C(C=3C1=CC=CC3)=CC(S(NC4=C(OC)N=C(OC)C=C4)(=O)=O)=CC2
Molecular Formula
C20H19N3O4S
Molecular Weight
397.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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