Nutlin-3a

• Target:

  Apoptosis|||E1/E2/E3 Enzyme|||Autophagy|||MDM-2/p53

• Related Pathways:

  Autophagy|||Apoptosis|||Ubiquitination

• Purity:

  0.9971

• Bioactivity:

  Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction (Ki=90 nM) and activates p53. Nutlin-3a binds preferentially to the p53-binding pocket of MDM2, leading to stabilization of p53 and activation of the p53 pathway. Nutlin-3a has antitumor activity.

• Smiles:

  COc1ccc(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1

• Molecular Formula:

  C30H30Cl2N4O4

• Molecular Weight:

  581.49

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  675576-98-4