Nec-3a

• Target:

  Others|||RIP kinase

• Related Pathways:

  Apoptosis|||Others|||NF-?B

• Bioactivity:

  Nec-3a, an analogue of Necrostatin-3, acts as a RIP1 inhibitor with an inhibition concentration (IC50) of 0.44 ?M. This compound successfully impedes the autophosphorylation activity within the RIP1 kinase domain.

• Smiles:

  C(CO)(=O)N1[C@@H]([C@]2(C(=N1)C=3C(CC2)=CC=C(OC)C3)[H])C4=CC(F)=C(OC(F)(F)F)C=C4

• Molecular Formula:

  C21H18F4N2O4

• Molecular Weight:

  438.37

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1504558-72-8