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Nutlin-3

CAT: 0931-T2158-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T2158-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
548472-68-0
Target
E1/E2/E3 Enzyme, MDM-2/p53
Related Pathways
Apoptosis, Ubiquitination
Purity
0.9989
Bioactivity
Nutlin-3 is an MDM2 antagonist that inhibits MDM2-p53 interaction (Ki=90 nM) and activates p53. Nutlin-3 binds preferentially to the p53-binding pocket of MDM2, leading to stabilization of p53 and activation of the p53 pathway. Nutlin-3 has antitumor activity.
Smiles
COc1ccc(C2=NC(C(N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1
Molecular Formula
C30H30Cl2N4O4
Molecular Weight
581.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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