Nutlin-3

• Target:

  E1/E2/E3 Enzyme|||MDM-2/p53

• Related Pathways:

  Apoptosis|||Ubiquitination

• Purity:

  0.9989

• Bioactivity:

  Nutlin-3 is an MDM2 antagonist that inhibits MDM2-p53 interaction (Ki=90 nM) and activates p53. Nutlin-3 binds preferentially to the p53-binding pocket of MDM2, leading to stabilization of p53 and activation of the p53 pathway. Nutlin-3 has antitumor activity.

• Smiles:

  COc1ccc(C2=NC(C(N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1

• Molecular Formula:

  C30H30Cl2N4O4

• Molecular Weight:

  581.49

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  548472-68-0