GNE-064

CAT: 0931-T60079-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T60079-01Size:1 mg
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CAS Number
1997321-20-6
Target
Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic
Purity
0.9991
Bioactivity
GNE-064 is a selective, orally active and highly soluble inhibitor of SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 ?M and inhibits SMARCA2 with an EC50 of 0.10 ?M. GNE-064 possess Kds with 0.01, 0.016, 0.018 and 0.049 ?M for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of drug synthesis.
Smiles
C[C@@H]1CN(CCN1C(C)=O)c1cc(nnc1N)-c1ccccc1O
Molecular Formula
C17H21N5O2
Molecular Weight
327.38
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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