GNE-064

• Target :

  Epigenetic Reader Domain

• Related Pathways :

  Chromatin/Epigenetic

• Purity :

  0.9991

• Bioactivity :

  GNE-064 is a selective, orally active and highly soluble inhibitor of SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 ?M and inhibits SMARCA2 with an EC50 of 0.10 ?M. GNE-064 possess Kds with 0.01, 0.016, 0.018 and 0.049 ?M for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of drug synthesis.

• Smiles :

  C[C@@H]1CN(CCN1C(C)=O)c1cc(nnc1N)-c1ccccc1O

• Molecular Formula :

  C17H21N5O2

• Molecular Weight :

  327.38

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1997321-20-6