TP-064

• Target:

  Histone Methyltransferase

• Related Pathways:

  Chromatin/Epigenetic

• Purity:

  0.9907

• Bioactivity:

  TP-064 is a potent and selective PRMT4 inhibitor, featuring an IC50 < 10nM for methylation of H3 (1-25) and over 100-fold selectivity compared to other histone methyltransferases and non-epigenetic targets. It inhibits the methylation of MED12 in cells with an IC50 of 43 nM.

• Smiles:

  CNCCN1CCC(CC1)c1cc(CN(C)C(=O)c2cccc(Oc3ccccc3)c2)ccn1

• Molecular Formula:

  C28H34N4O2

• Molecular Weight:

  458.6

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2080306-20-1