Products for Research Use Only
RegisterLogin

Proguanil hydrochloride

CAT: 0931-T4382-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T4382-01Size:1 mL - 10 mM (in DMSO)
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
637-32-1
Target
Dehydrogenase, Parasite, DNA/RNA Synthesis, Antifolate
Related Pathways
Metabolism, Microbiology/Virology, Cell Cycle/Checkpoint, DNA Damage/DNA Repair
Purity
0.9903
Bioactivity
Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
Smiles
Cl.Clc1ccc(NC(=N)NC(=N)NC(C)C)cc1
Molecular Formula
C11H17Cl2N5
Molecular Weight
290.19
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Proguanil Hydrochloride

Proguanil Hydrochloride is the hydrochloride salt form of proguanil, a synthetic biguanide derivative of pyrimidine and an folate antagonist with antimalarial property. Upon hydrolysis, proguanil is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.

CAS Number637-32-1
PubChem CID9570076
IUPAC Name(1E)-1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine;hydrochloride
Molecular FormulaC11H17Cl2N5
Molecular Weight290.19
Topological Polar Surface Area88.8
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count1
Rotatable Bond Count4
Heavy Atom Count18
Formal Charge0
Complexity292
SMILES
CC(C)N=C(N)/N=C(\N)/NC1=CC=C(C=C1)Cl.Cl
InChI
InChI=1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H
InChIKey
SARMGXPVOFNNNG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Proguanil Hydrochloride
CAS: 637-32-1
CID: 9570076
Formula: C11H17Cl2N5
MW: 290.19
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight290.19
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count1
Rotatable Bond Count4
Exact Mass289.0861010
Monoisotopic Mass289.0861010
Topological Polar Surface Area88.8 Ų
Heavy Atom Count18
Formal Charge0
Complexity292
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
T22409-01Proguanil
T12545-01Proguanil D6
TMIH-0457-01Proguanil-d6 HCl
T77217Saccharopine hydrochloride
T23379-01Solifenacin hydrochloride
T38447-01BN82002 hydrochloride
T40896Bromchlorbuterol hydrochloride
T33939-01Dagrocorat hydrochloride
T36365-01KAPA hydrochloride
T0204Protriptyline hydrochloride

Alternative Products

CatalogName
GL3057-10mgProguanil hydrochloride
HY-B0806A-01Proguanil (hydrochloride)
HY-B0806AS1-01Proguanil-d6 (hydrochloride)
HY-B0806AS-01Proguanil-d4 (hydrochloride)
HY-B0806ARProguanil (hydrochloride) (Standard)
RM-P150701-01Proguanil Hydrochloride EP Impurity A
RM-P150703-01Proguanil Hydrochloride EP Impurity C
RM-P150704-01Proguanil Hydrochloride EP Impurity D
RG-C081227-01Chlorhexidine EP Impurity P; Proguanil hydrochloride EP Impurity B
S5927-01Proguanil

Popular Products