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Proguanil hydrochloride

CAT: 0931-T4382-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0931-T4382-01Size:1 mL - 10 mM (in DMSO)
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
637-32-1
Target
Dehydrogenase, Parasite, DNA/RNA Synthesis, Antifolate
Related Pathways
Metabolism, Microbiology/Virology, Cell Cycle/Checkpoint, DNA Damage/DNA Repair
Purity
0.9903
Bioactivity
Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
Smiles
Cl.Clc1ccc(NC(=N)NC(=N)NC(C)C)cc1
Molecular Formula
C11H17Cl2N5
Molecular Weight
290.19
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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