Proguanil-d6 (hydrochloride)

• UNSPSC Description:

  Proguanil-d6 hydrochloride is the deuterium labeled Proguanil hydrochloride (HY-B0806A). Proguanil hydrochloride, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor[1][2][3].

• Target Antigen:

  Antifolate; Isotope-Labeled Compounds; Parasite

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Anti-infection;Cell Cycle/DNA Damage;Others

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Purity:

  98.73

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC(C=C1)=CC=C1NC(NC(NC(C([2H])([2H])[2H])C([2H])([2H])[2H])=N)=N.Cl

• Molecular Weight:

  296.23

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Pudney M, et al. Atovaquone and proguanil hydrochloride: a review of nonclinical studies. J Travel Med. 1999 May;6 Suppl 1:S8-12.|[3]Srivastava IK, et al. A mechanism for the synergistic antimalarial action of atovaquone and proguanil. Antimicrob Agents Chemother. 1999 Jun;43(6):1334-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported