Proguanil

• Target:

  Parasite|||DNA/RNA Synthesis|||Antifolate

• Related Pathways:

  DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Microbiology/Virology

• Purity:

  0.996

• Bioactivity:

  Proguanil (Chloroguanide) is a prophylactic antimalarial drug that acts primarily through its active metabolite, Cycloguanil, which inhibits the dihydrofolate reductase (DHFR) enzyme of Plasmodium falciparum, preventing the synthesis of purines and pyrimidines and inhibiting the growth and reproduction of the parasite.

• Smiles:

  ClC1=CC=C (C=C1) NC (=N) NC (=N) NC (C) C

• Molecular Formula:

  C11H16ClN5

• Molecular Weight:

  253.73

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  500-92-5