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Proguanil-d6 HCl

CAT: 0931-TMIH-0457-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-TMIH-0457-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Parasite, Antifolate
Related Pathways
Cell Cycle/Checkpoint, Microbiology/Virology
Bioactivity
Proguanil-d6 HCl is a deuterated compound of Proguanil HCl. Proguanil HCl has a CAS number of 637-32-1. Proguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, proguanil is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
Smiles
N=C(NC(NC(C([2H])([2H])[2H])C([2H])([2H])[2H])=N)NC1=CC=C(Cl)C=C1.Cl
Molecular Formula
C11H11D6Cl2N5
Molecular Weight
296.23
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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