Proguanil-d4 (hydrochloride)

Proguanil-d4 (hydrochloride)

• CAS Number: 1189671-34-8
• UNSPSC Description: Proguanil-d4 (hydrochloride) is the deuterium labeled Proguanil hydrochloride. Proguanil hydrochloride, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor[1][2].
• Target Antigen: Antifolate; Isotope-Labeled Compounds; Parasite
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection;Cell Cycle/DNA Damage;Others
• Field of Research: Infection
• Solubility: 10 mM in DMSO
• Smiles: CC(C)NC(NC(NC1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)=N)=N.Cl
• Molecular Weight: 294.22
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Pudney M, et al. Atovaquone and proguanil hydrochloride: a review of nonclinical studies. J Travel Med. 1999 May;6 Suppl 1:S8-12.|[3]Srivastava IK, et al. A mechanism for the synergistic antimalarial action of atovaquone and proguanil. Antimicrob Agents Chemother. 1999 Jun;43(6):1334-9.|[4]Lochner M, et al. The antimalarial drug proguanil is an antagonist at 5-HT3 receptors. J Pharmacol Exp Ther. 2014 Dec;351(3):674-84.|[5]Stephen AO, et al. Prolonged administration of proguanil induces reproductive toxicity in male rats. J Toxicol Sci. 2011 Oct;36(5):587-99.|[6]Iguchi A, et al. The in vitro interactions and in vivo efficacy of atovaquone and proguanil against Babesia gibsoni infection in dogs. Vet Parasitol. 2013 Nov 8;197(3-4):527-33.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported