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Zanapezil free base

CAT: 0931-T38895Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T38895Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
142852-50-4
Target
Others, Cholinesterase (ChE)
Related Pathways
Others, Neuroscience
Bioactivity
Zanapezil (TAK-147) is a powerful and selective inhibitor of acetylcholine esterase (AChE) . It demonstrates significant and reversible inhibition of AChE activity in rat cerebral cortex homogenates (IC50 = 51.2 nM) . Furthermore, Zanapezil exhibits moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. This compound holds promise for the investigation of the initial stages of Alzheimer's disease (AD) .
Smiles
O=C(CCC1CCN(Cc2ccccc2)CC1)c1ccc2CCCCNc2c1
Molecular Formula
C25H32N2O
Molecular Weight
376.544
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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