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AMG 21629

CAT: 0931-T37732Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T37732Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
939040-79-6
Target
Others, TRP/TRPV Channel
Related Pathways
Membrane transporter/Ion channel, Others
Bioactivity
Potent and selective TRPV1 antagonist. Blocks Ca2+ uptake by CHO cells expressing TRPV1 receptors and acid-induced Ca2+ uptake, respectively) . Exhibits >4000-fold selectivity for TRPV1 over other TRP channels. Blocks capsaicin-induced flinch response and causes hyperthermia in rats. Orally available and non-CNS penetrant.
Smiles
O(C1=C2C(NC(=O)C(N)=N2)=CC=C1)C=3C=C(N=C(NCCOC)N3)C4=CC=C(C(F)(F)F)C=C4
Molecular Formula
C22H19F3N6O3
Molecular Weight
472.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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