AMG 21629

• Target:

  Others|||TRP/TRPV Channel

• Related Pathways:

  Membrane transporter/Ion channel|||Others

• Bioactivity:

  Potent and selective TRPV1 antagonist. Blocks Ca2+ uptake by CHO cells expressing TRPV1 receptors and acid-induced Ca2+ uptake, respectively) . Exhibits >4000-fold selectivity for TRPV1 over other TRP channels. Blocks capsaicin-induced flinch response and causes hyperthermia in rats. Orally available and non-CNS penetrant.

• Smiles:

  O(C1=C2C(NC(=O)C(N)=N2)=CC=C1)C=3C=C(N=C(NCCOC)N3)C4=CC=C(C(F)(F)F)C=C4

• Molecular Formula:

  C22H19F3N6O3

• Molecular Weight:

  472.42

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  939040-79-6